Non-absorbable sutures consist of non-biodegradable material, so they can not be digested by enzymes or hydrolyzed in tissues.

Ultimately, fibroblasts encapsulate them permanently, so they maintain their maximum resistance over time, except in the case of being removed stitches in the post-surgical (skin suture).

There are different types of non-absorbable sutures with different levels of resistance. They can be monofilament or multi-filament which will be selected depending on the tissues to be sutured or at the discretion of the professional.